Peyton Manning vs. San Diego

Tony Romo vs. San Francisco

SLEEPERS

Gus Frerotte vs. Jacksonville: Frerotte was asked to do very little last Sunday, and as a result, his offense was lifeless. This week, Frerotte can throw with abandon against a shockingly bad Jacksonville defense that has allowed the second-most scoring throws, including touchdown passes in every game.

Jason Campbell vs. Seattle: After starting the season well, Campbell has been lousy for more than a month, passing for just three touchdowns in the past six games. But he has a nice opportunity this week. Seattle has allowed the second-most passing yards and 14 touchdowns this season.

CAUTION

Jay Cutler vs. Oakland: Remember when Cutler carved up the Raiders in the season opener? Well, you're better off forgetting it because Oakland's secondary is good. Only three quarterbacks have thrown for more than one score, and only four have topped 197 yards.

Matt Ryan vs. Carolina: Ryan might be the best story of the season, but his string of successes could come to a halt this week. The Panthers shut him down in Week 4, holding Ryan to 158 yards and no scores. Since the opener, Carolina has allowed only five passing touchdowns.

NO-BRAINERS

Matt Forte vs. St. Louis

LaDainian Tomlinson vs. Indianapolis

Maurice Jones-Drew vs. Minnesota

SLEEPERS

Warrick Dunn vs. Detroit: Earnest Graham is done for the season, so Dunn will get the lion's share of the carries. The Lions have allowed the second-most rushing yards and third-most touchdowns to opposing running backs.

Justin Fargas vs. Denver: Until today, I'm not sure that any Raider has graced the "sleeper" category this season. Welcome, Justin Fargas! It's all about the matchup. Denver has allowed the third-most running back scores and ranks 26th against the run.

CAUTION

Chris Johnson vs. New York Jets: After starting the season on fire, it looks like Johnson has hit the rookie wall. In his past two games, he has been held scoreless, totaled just 72 rushing yards and is averaging 2.3 yards a carry. The Jets haven't allowed a rushing score in six weeks, and no opposing back has topped 74 yards.

Tim Hightower vs. New York Giants : Hightower has been ineffective for two weeks, in part because he's losing touches to J.J. Arrington. This week's assignment won't help matters. The Giants have allowed just three rushing touchdowns all season and rank eighth against the run.

NO-BRAINERS

Andre Johnson vs. Cleveland

Steve Smith vs. Atlanta

Greg Jennings vs. New Orleans

SLEEPERS

Torry Holt vs. Chicago: Holt is in the middle of a horrible season, but he's much better at home than away. Holt has scored 14 of his past 15 touchdowns at home. His opponent this week, Chicago, has allowed the second-most yardage to opposing wide receivers.

Antonio Bryant vs. Detroit: Bryant is as close to a go-to receiver as anyone in Tampa Bay. And, needless to say, a matchup with Detroit is tantalizing. Only five teams have allowed more yardage to opposing wide receivers, and only two have allowed more touchdowns.

CAUTION

Chris Chambers vs. Indianapolis: In the three games since his return from injury, Chambers has yet to score and has totaled just 68 yards. The Colts are allowing the second-fewest yards to opposing wide receivers, and the fewest touchdowns, just one all season.

Marques Colston vs. Green Bay: Increasingly, Colston looks like just another receiver in the crowded Saints offense. Since his return, he has yet to score and is averaging just 54 yards a game. Green Bay is allowing the fewest yards to opposing wide receivers.

NO-BRAINERS

Antonio Gates vs. Indianapolis

Dallas Clark vs. San Diego

SLEEPERS

Bo Scaife vs. New York Jets: Quietly, Scaife leads the undefeated Titans in receptions and yards. The Jets have allowed the second-most scores to tight ends, including scores in three of the past four games. Even lower tier guys such as David Martin, Ben Watson and Derek Fine have scored.

CAUTION

Jason Witten vs. San Francisco: Witten has been silent since his rib injury. He hasn't scored, and he has managed just 14 yards a game. San Francisco is allowing the fewest yards to opposing tight ends, just 17 a game.